Studies on Improving Solubility in Different Media for Said Formulations with Topical Application
Keywords:topical application, oxicams, piroxicam, meloxicam, tenoxicam.
AbstractThe studied compounds are gels with meloxicam, piroxicam and tenoxicam in different solvents. The problem of solubilization of these compounds is generated by their poor solubility in hydrophilic media. Also, when applying local non-steroidal anti-inflammatory drugs (NSAIDs) in the form of ointments, the local concentration of the active substance is much higher than in the untreated tissue. The amount of NSAIDs required to produce a therapeutic effect by topical administration is much lower than in oral administration. Side effects may, however, occur as a local irritation from the time a topical formulation is applied. This paper presents the solubilization tests performed for pharmaceutical compounds of the NSAID class in different hydrophilic media. The test conclusions are useful because their solubility can be increased by using solvents (polar or non-polar) and surfactants. The conclusions of the solubility tests help in choosing solvents in the formulation and technologicalization of semi-solid preparations with topical application.